What Is Their Main Difference?
Their main difference is that they have different grammatical functions. 'Loss' is a noun, whereas, 'lost' is the simple past tense of the verb 'lose'. Look at the examples below:
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Both indicate not having access to someone or something anymore. Look at the examples below:
Are They Interchangeable?
They cannot be used interchangeably because they have different grammatical functions. Compare: