to depress
[动词]
to make someone feel extremely sad or discouraged, often as a result of challenging situations, such as loss

使沮丧, 使忧伤
to desolate
[动词]
to make someone feel extremely miserable and unhappy

使人感到凄凉, 使人感到绝望
Ex: Failure to achieve his lifelong desolated him with a sense of hopelessness .
to disappoint
[动词]
to fail to meet someone's expectations or hopes, causing them to feel let down or unhappy

使失望, 让人失望
to disgust
[动词]
to make someone feel upset, shocked, and sometimes offended about something

使感到厌恶, 让人反感
to gross out
[动词]
to disgust someone, especially with something vulgar or offensive

让人恶心, 使人作呕
Ex: The graphic content in the TV show grossing out the audience .
to wear out
[动词]
to make someone tired because of strain or stress

耗尽, 使疲惫
Ex: The constant pressure wore out his enthusiasm for the job .
to bore
[动词]
to do something that causes a person become uninterested, tired, or impatient

使...乏味, 使...厌烦
to stultify
[动词]
to make someone lose interest or motivation, typically due to a boring or restrictive routine

使某人失去兴趣, 使某人丧失动力

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